Archive for September, 2015
Copper Tripeptide-1 has been shown to play a role in stimulating the production of collagen, aid in wound healing and tissue remodeling. It also has Antioxidant, Anti-Inflammatory, Anti Microbial and Anti-Tumor Effects.
What is Copper Tripeptide-1
Copper Tripeptide-1 is naturally occurring in the body, it is composed of the amino acids Glycyl-histidyl-lysine, which spontaneously binds to copper, also known as GHK-CU. Copper Tripeptide-1 has many benefits within the human body, however levels decrease with age. Given the benefits that it has for renewing, repairing and protecting the skin, it makes sense that this would be used in cosmeceutical skin care products.
Copper Tripeptide-1 is used topically for anti-aging and firming of the skin. As we age our skin becomes progressively thinner, this is due in part to the declining production of collagen in the dermis and keratinocytes in the epidermis. As we age the skins ability to protect and repair itself also declines and this contributes to the degradation or breakdown of collagen. Copper Tripeptide-1 plays a role in stimulating collagen production and in the proliferation of keratinocytes. This is very promising for anti-aging skin care
Wound Healing and Tissue Remodeling
Copper Tripeptide-1 is seen to play a role in accelerating wound healing and improved tissue remodeling. Studies done on diabetic wounds, showed that wounds healed up to three times faster and had a lower incidence of infection, in the presence of Copper Tripeptide-1. This is relevant to anti-aging, because as we age the levels of GHK-CU decrease, which can affect the ability for skin to repair and renew it’s self. Further more, many of the treatments used to improve skin appearance, take advantage of the skins wound healing ability to increase the production of collagen, elastin and hyaluronic acid. The more effective the skins wound healing ability is, the more effective the treatment may be.
Anti-Tumor and Protective Ability
Radiation from sun exposure and cancer treatments have damaging effects on DNA and induce aging. Copper Tri-petide-1 (GHK-CU) helps to protect DNA from these damaging effects. Tumor cell lines died in the presence of Copper Tri-peptide, however healthy cell lines were protected. Skin fibroblasts, are “master cells” responsible for producing collagen, elastin and hyaluronic acid. Fibroblast exposed to radiation have been shown to restore their function when in the presence of (GHK-CU).
Antioxidant, Anti-Inflammatory and Anti-Microbial Effects
Intrinsic antioxidants, are antioxidants that the body makes, they can not be obtained with diet. With age, the production of these intrinsic antioxidants declines. Some of these intrinsic antioxidants are induced by Copper Tripeptide-1. It also has anti-inflammatory and anti-microbial effects during wound healing and tissue remodeling stages.
Skin Care Products with Copper Tripeptide-1
Topical products with Copper Tripeptide-1 may be useful for post procedure skin care to enhance results. They definitely look to be a promising as part of an anti-aging skin care regimen, especially when used with other power house products such as retinoids, anti-oxidants and most importantly broad spectrum sun protection.
Innovative Skin Care has added Copper Tripeptide-1 to many of their iS Clinical line of skin care products, including the most recent “Youth Serum” which is quickly becoming an A-list favorite. It is also found in Super Serum Advance +, Reparative Moisture Emulsion, Youth Intensive Cream, Youth Complex and Youth Eye Complex.
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There are countless skin care products available to treat skin discolorations known as “hyperpigmentation”, such as brown spots and melasma. There is also just as much confusion and misinformation, surrounding topical Hydroquinone and Non- Hydroquinone products. The fact is they are both necessary, as each have a place in correcting and maintaing pigment irregularities.
I am a proponent for Hydroquinone and for good reason, when used correctly it is arguably the most effective topical for treating hyperpigmentation. I am also a proponent for Non-Hydroquinone skin brighteners, because I do not support using Hydroquinone indefinitely without pulsing on and off.
If you understand how hyper pigmentation occurs, you are better able to understand how to treat it. The process of producing pigment (melanogenesis) is complex, with many process, so I am giving the short version. When the skin has hyperpigmentation, it means that, there are melanocytes that are over producing melanin (pigment) AND that those pigment cells are not being evenly distributed to the skin cells called keratinocytes.
Something must first, trigger the increase of tyrosinase activity, this can be sun exposure, hormones or inflammation. Tyrosinase is an enzyme in the skin that controls the production of melanin. One of the main goals in treating hyperpigmentation is to inhibit the tyrosinase, so that it will not trigger the overproduction of melanin (pigment). Products that aim to do this use ingredients that we call “tyrosinase inhibitors”. Hydroquinone is a strong tyrosinase inhibitor, however there are also non-hydroqinone tyrosinase inhibitors that are effective.
Hydroquinone is a strong tyrosinase inhibitors and very effective at treating hyper pigmentation. There is concern, however that with extended use the skin may become resistant to the effects. This is why it is important to use hydroquinone under professional guidance. The general idea is to maximize correction, before you build resistance. Many dermatologists and skincare professionals are now recommending pulsing on and off hydroquinone. If you are using or plan on using hydroquionone products, I recommend you read “Hydroquinone: What you need to know, to maximize it’s benefits and prevent resistance”.
When you are pulsing off hydroquinone, you may want to use a non-hydroquinone skin brighter. Look for a brightener with tyrosinase inhibitors. Ideally, non-hydroquinone skin brighteners should be formulated with a combination of ingredients that will have an effect on the various stages of melanogensis (the formation of pigments). Antioxidants and exfoliants play a role in melanogensis and should be part of a skin care regimen, along with a tyrosinase inhibitor. I am including a short list of some commonly used ingredients in Non-hydroquinone brighteners.
Non-Hydroquinone Lighting/ Brighting Ingredients
Arbutin (Bearberry Extract)
Licorice Root Extract
Hydroxyphenoxy Propionic Acid
For best results begin by preparing your skin to best absorb the topical products you are using, this is done by properly cleansing and toning skin. Topical antioxidants and a broad spectrum SPF, are a MUST, because they help block the effects of “triggers”. We also recommend some type of chemical exfoliant, such as glycolic or lactic acid. These help by exfoliating melanin filled skin cells from the surface, which accumulate and cause pigment to be more dense, making it look darker. Retinoids such as tretinoin (Retina-A) work by inhibiting the transfer of pigment to skin cells, this blends pigment for even skin tone. Retinoids also work as a tyrosinase inhibitor. Finally, if you are not seeing the results you want with topical products alone, consult with a skin care provider to discuss which treatment options are best for you. Typically, we recommend chemical peels or PhotoFacials (IPL or BBL), depending on skin type and conditions being treated.
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Most of us are exposed to environmental stressors daily that can damage structural proteins within the skin such as collagen and elastin, as well as essential genetic DNA. This equals skin aging, with loss of elasticity, resilience, immune function and cancer resistance. Science has found in nature, a way to help protect fragile and vital structures in human skin, from extreme and daily stressors.
If you have never been to Arizona, then you probably have not seen a live Saguaro Cactus. The saguaro cactus is unique to the Arizona Sonoran Desert, as well as Sonora Mexico, and California along the Arizona and Mexico borders. The saguaro thrives in these extreme desert environments, because it is an extremophile that loves very dry, hot climates.
Extremozymes are protective enzymes derived from extremophiles, which are organisms that thrive in extreme environments, that would be detrimental to most life on earth. Extreme environments include places with extreme tempetures, PH or altitude. Examples are the deepest, dark parts of the ocean, Antartica or a dry desert. These extreme environments would otherwise denature typical enzymes, but extremophiles develop protective enzymes (extremozymes) that cushion and protect vital structures, kind of like bubble wrap. Many Extremozymes assist these organisms in not only protecting, but repairing DNA as it is damaged by environmental factors.
INNOVATIVE SKINCARE®’s Extremozyme® products utilize the survival advantages from these extremophilic organisms to protect and preserve skin from environmental damage and aging by combating moisture loss, dehydration, radiation, heat, cold, and free radical damage. We like iS Clinical “Youth Serum” and “Reparative Moisture Emulsion” which are both formulated with Extremozymes. Your skin care survival kit should also include an antioxidant serum and broad spectrum SPF. We recommend starting a skin care regimen with extremozymes, topical antioxidants and sunblock in your 20’s, because aging starts sooner than you think.
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CoolSculpting is a non-surgical fat freezing procedure that contours the body by safely and effectively freezing away unwanted fat permanently. It has become a popular option for those who do not have the time to recover from liposuction. CoolSculpting is commonly used to treat problem areas like loves handles, stomach rolls, back fat, inner and outer thighs.
The price for CoolSculpting varies greatly, depending on your areas of concern, the number of treatments needed and your ultimate goals. Typically, you’ll see a noticeable reduction of fat in the treated area after one visit, but you may appreciate even more fat reduction with additional treatments. About 20% of the fat cells are eliminated with a single treatment, most people should expect to do two treatment cycles on each area treated. Occasionally, more than two treatment cycles are needed to achieve your personal desired results
The biggest variable is the amount of applicators and the size of the applicators needed to address the area of concern. Multiple applicators are typically needed to treat each area, it is not possible to determine how many or which applicators are needed without an in office assessment. Most CoolSculpting providers offer special pricing with multiple applicators. Generally the more applicators needed, the greater the value with a lower per applicator price.
CoolSculpting is not something you will be able to price shop over the phone or on the internet. You need an in office consultation, so that you can be assessed to determine if you are a good candidate for Coolsculpting and if so which and how many applicators are needed to treat your specific are of concern. During your consultation you can work with your provider to create a customized treatment plan, that’s tailored to your body, your goals, and your budget. If you are interested in financing, ask if your provider will except http://www.carecredit.com
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